Book Details

Hardcover: 752 pages
Publisher: Lippincott Williams & Wilkins; Second edition (January 1, 1990)
Language: English
ISBN-10: 0397507208
ISBN-13: 978-0397507207.

Book Description

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Book Details

Hardcover: 1184 pages
Publisher: Lippincott Williams & Wilkins; Har/Psc edition (July 26, 2010)
Language: English
ISBN-10: 1608319040
ISBN-13: 978-1608319046.

Book Description

It is indeed the merit of Dr. Alan F. Casy to bring in these pages a clear and comprehensive view of medicinal stereochemistry, a discipline in which he has been active and successful for many years both as a teacher and a researcher. Written for graduate students and research workers in medicinal chemistry and pharmacology, this book will contribute significantly towards a better education of scientists by removing the fear of stereochemistry caused by ignorance, moderating the overconfidence of possible zealots, and outlining a broader context.’-from the foreword by Bernard Testa.

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Book Details

Hardcover: 336 pages
Publisher: World Scientific Publishing Company; 1 edition (October 15, 2008)
Language: English
ISBN-10: 9789812778932
ISBN-13: 978-9812778932.

Book Description

Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.

This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer’s and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.

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Book Details

Hardcover: 860 pages
Publisher: Springer; 1 edition (August 27, 2008)
Language: English
ISBN-10: 9783540766971
ISBN-13: 978-3540766971.

Book Description

This manual describes laboratory methodology for diagnosing inborn errors of metabolism. Each chapter is sufficiently detailed so as to be self-contained, thus enabling any individual to adopt the method in their own laboratory and obviating the need for additional methods of references. The book is unique in that it is the first of its kind to be published in the last 15 years, and individual chapters have been developed by experts in the field citing both established and ‘cutting-edge’ technology.

Thus, it is sufficiently up-to-date to be applicable to the field of inborn errors of metabolism for all readers and those interested in laboratory diagnosis.

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Book Details

Hardcover: 608 pages
Publisher: Academic Press; 1st edition (July 25, 1995)
Language: English
ISBN-10: 0125138407
ISBN-13: 978-0125138406.

Book Description

In recent years, rapid technological advances and changes in agricultural management have taken place. These have yielded benefits to society but have also generated new and significant environmental problems. Novel questions and challenges relating to agricultural practice and soil microbial ecology, ecotoxicology, biotechnology, and bioremediation must be addressed. As a consequence, the fields of soil microbiology and biochemistry have been highlighted.

This book provides a modern, authoritative, and comprehensive collection of methods for the study of soil microbiology and biochemistry. Classical and modern, aerobic and anerobic, laboratory and field-based methods are presented. Detailed techniques are given, but in addition the theoretical basis behind such methodology is described, so that the origins and principles of the techniques are clear to the reader. Particular emphasis has been placed on uniform, simple, and clear presentation of the different methods.

With respect to bioremediation of soils, this work provides a unique bridge between general and applied soil microbiology and biochemistry, presenting an integrated discussion of concepts, theories, and methods. This book will be essential for all scientists and students actively involved in natural and environmental sciences and engineering, and for those working in industry, authorities, and consulting companies.

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Book Details

Hardcover: 208 pages
Publisher: Springer; 1st edition (June 30, 1999)
Language: English
ISBN-10: 0792382641
ISBN-13: 978-0792382645.

Book Description

The papers in this volume were contributed by close friends, co-workers and pupils of Professor Setsuro Ebashi. They are dedicated to him to commemorate his great and pioneering contribution to the advancement of muscle physiology and biochemistry, which, in time, exerted a great influence on the whole field of life science. We believe that this issue reveals the present state of research on muscle and/or calcium that was opened up by Professor Ebashi.

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Book Details

Paperback: 270 pages
Publisher: Springer; 1st Edition. edition (November 2, 2010)
Language: English
ISBN-10: 144193068X
ISBN-13: 978-1441930682.

Book Description

Seeming sometimes more like science fiction than science, anaerobic bacteria have been at the center of a number of exciting new discoveries. This volume discusses and explains the diversity of metabolism, modes of protein transport, molecular biology and physiology of these unusual microbes. It has practical applications ranging from wastewater treatment to clinical diagnosis and treatment of medical conditions.

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Book Details

Hardcover: 149 pages
Publisher: Springer; 1 edition (December 6, 2007)
Language: English
ISBN-10: 3540737995
ISBN-13: 978-3540737995.

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Book Details

Hardcover: 244 pages
Publisher: Springer; 1 edition (April 30, 1990)
Language: English
ISBN-10: 0412358409
ISBN-13: 978-0412358401.

Book Description

This is a study based on the proceedings of a workshop concerned with extracellular virulence factors of mucoid strains of Pseudomonas aeruginosa in relation to Cystic Fibrosis. It is intended to further the understanding of mucoid P. aeruginosa infections and to provide benefit to those who need it most – the children and adults suffering from CF. It focuses on alginate as an extracellular virulence factor of P.aeruginosa in CF pulmonary infections and presents advances in the biochemistry and molecular genetics of alginate biosynthesis and the basic defect in CF and isolation of the gene. The non-mucoid to mucoid transformation “in vitro” and “in vivo” are discussed in relation to host responses to alginate. The structure, properties, and biosynthesis including genetics of alginate are dealt with in detail and related to its chemical physical and biological properties.

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Book Details

Hardcover: 508 pages
Publisher: Elsevier Science; 1 edition (July 5, 1996)
Language: English
ISBN-10: 1559388080
ISBN-13: 978-1559388085.

Book Description

This volume is intended to complete the Cell Chemistry and physiology module. It is about how the traditional boundaries of cell chemistry and physiology are being erased by molecular biology. We do not think it necessary to elaborate on this theme, particularly since the body of core knowledge found in this volume brings us a stage closer to answering the question, “what makes cell biology into a new discipline?” The first part of the volume deals with the chemistry of actin and myosin and is followed by chapters on cell motility, ATP synthesis in muscle, and contraction in smooth and skeletal muscle. Here the reader is immediately made aware of the contributions molecular biology is making to our understanding of the molecular mechanisms underlying muscle contraction. It is perhaps enough to point out that Huxley’s concept of the cross-bridge cycle and generation of force can now be explained in molecular terms. Topics such as muscle fatigue and muscle disorders, as well as malignant hyperthermia are bound to arouse active learning in the student and set the stage for problem-based learning. Most medical students look askance at thermobiology. We think this is a mistake; hence, we have included a section dealing with this subject. This brings us to the chapter on the heat shock response, which at the very outset makes clear that many stressors besides heat are known to result in heat shock gene expression. Many of the heat shock proteins occur in unstressed cells and some of them behave as chaperones. These proteins also reach high levels in a wide range of diseases including neurodegenerative disorders. Whether certain diseases are the result of mutations in the heat shock genes is not yet known. As will be appreciated, much of the work done in this field involved the use of cultured cells. Animal cells in culture are the subject of the last chapter.

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