Book Details

Paperback: 144 pages
Publisher: CRC-Press; 1 edition (February 1, 1997)
Language: English
ISBN-10: 0849333334
ISBN-13: 978-0849333330.

Book Description

Biochemical Techniques in the Heart fully describes classical biochemical measurements of parameters involved in contraction and relaxation in the heart. This fully detailed guide tells you how to make preparations of sarcoplasmic reticulum, sarcolemma, and cardiomyocytes and how to measure sodium-calcium and sodium-hydrogen exchange. Two chapters explain the measurement of the important enzyme sodium-potassium ATPase. This book examines the most widely used tools in experimental cardiology and provides you with the recipe-setting up the technique, procurement of equipment, sample data and calculations, problems and trouble shooting, adapting to other species, modifications, and applicability. Undoubtedly, this text will be a great asset to cardiovascular physiologists, pharmacologists, experimental cardiologists, and students of physiology and pharmacology.

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Book Details

Hardcover: 272 pages
Publisher: CRC Press; 1 edition (June 22, 2000)
Language: English
ISBN-10: 0849307449
ISBN-13: 978-0849307447.

Book Description

Years of extensive investigation into neurophysiology, neurochemistry, and behavioral pharmacology have produced an understanding of antipsychotic medication action that is much more refined than the original dopamine hypothesis. New perspectives offer an array of novel drugs – drugs that pose a lower risk of developing tardive dyskinesia, have fewer extrapyramidal side effects, are less sedating, and attempt to address the negative symptoms of schizophrenia. Neurotransmitter Receptors in Actions of Antipsychotic Medications presents a glimpse into the development of these breakthroughs and the field’s current status in one definitive volume.The exhaustive chapters cover the basic knowledge of schizophrenic syndromes and provide a general description of available antipsychotic drugs. Leading specialists recount the investigation into a variety of receptors in drug action and present unique topics like endogenous receptor occupation by antipsychotic drugs and regulation of brain receptors. The book also includes a survey of the future perspectives in drug design.Each year, pharmaceutical companies invest billions of dollars in developing hundreds of medications to treat psychiatric disorders. Neurotransmitter Receptors in Actions of Antipsychotic Medications helps you study and appreciate the dynamics of these medications. You will understand the effects on receptors; predict the action, adverse side effects, and drug-drug interactions; and improve the modern antipsychotic medications that already enable people coping with schizophrenia to work, have meaningful social relationships, and live more productive lives.

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Book Details

Hardcover: 360 pages
Publisher: CRC Press; 1 edition (March 6, 2002)
Language: English
ISBN-10: 0849300738
ISBN-13: 978-0849300738.

Book Description

Recent research in cell death mechanisms has rekindled interest in PARP’s (Poly (ADP-Ribose) Polymerase) intriguing role in necrosis and apoptosis. While the details of how PARP1 functions are still being elucidated, it has tremendous potential as a promising drug target. PARP inhibitors’ dual actions of preventing cell death and abating inflammation have demonstrated remarkable acute effects in animal models of various diseases. PARP as a Therapeutic Target covers the clinical aspects of this up-and-coming drug that counteracts the damage done by free radicals. Leading international experts currently working on ways to apply it share their views of recent developments and future directions of PARP research. They discuss its therapeutic potential in various disease conditions, such as ischemia, diabetes, cancer, arthritis, inflammatory bowel disease, and septic shock.The intensified PARP drug development effort has raised expectations for possible clinical trials in the near future to establish the tolerance of PARP inhibitors in healthy humans, its efficacy in treating patients with different diseases, and the long term effect of PARP inhibition. PARP as a Therapeutic Target provides a comprehensive understanding of how PARP works to aid in the better design of its inhibitors for therapeutic purposes.

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Book Details

Hardcover: 1194 pages
Publisher: CRC Press; 1st edition (December 15, 2000)
Language: English
ISBN-10: 0824789598
ISBN-13: 978-0824789596.

Book Description

A text and reference concerning the metabolism, functions, properties, pharmacological and toxicological effects, and other factors related to drug residues in food. For anyone involved in food control and safety.

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Book Details

Hardcover: 424 pages
Publisher: CRC Press; 2nd edition (March 15, 1993)
Language: English
ISBN-10: 0824788192
ISBN-13: 978-0824788193.

Book Description

McGill University, Montreal, Quebec. Clinical Pharmacology, Volume 18. New edition of a text on the stereoisomeric composition of drug substances as an aspect in the development, approval, and clinical use of pharmaceuticals. 19 contributors, 13 U.S. DNLM: Chemistry Pharmaceutical – methods.

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Book Details

Hardcover: 593 pages
Publisher: Springer; 1 edition (August 31, 1996)
Language: English
ISBN-10: 0792339134
ISBN-13: 978-0792339137.

Book Description

Knowledge of cardiac ion channels and transporters has advanced remarkably in the last two decades with the development of patch-clamp and molecular biological techniques. This textbook offers a comprehensive overview of structures and functions of ion channels and transporters in the heart. Readers are first introduced to the molecular biology and electrophysiology of all the important ion channels. After discussing their developmental changes, the pharmacology and pathophysiology of clinically-relevant ion channels are reviewed. Molecular aspects of the cardiac excitation-contraction coupling and intracellular Ca2+ regulation by ion transporters are also described. The book will be useful to electrophysiologists, cardiac physiologists and pharmacologists, and molecular biologists interested in ion channels at all levels. For research specialists, the book will provide a perspective of the field. The book can be used as a reference source for working scientists in the fields of ion channels, biophysics, cardiac electrophysiology, and pharmacology. It is aimed at graduate and medical students, designed for use as a textbook for graduate and medical courses.

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Book Details

Hardcover: 445 pages
Publisher: Springer; 1 edition (October 31, 1993)
Language: English
ISBN-10: 0792325184
ISBN-13: 978-0792325185.

Book Description

This volume represents the proceedings of the invited lectures of the second International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics, which was held in Houston, September 1992, under the co-sponsorship of the Serotonin Club, Baylor College of Medicine, the Giovanni Lorenzini Medical Foundation (Houston), and the Fondazione Giovanni Lorenzini (Milan). The symposium brought together pharmacologists, physiologists, molecular biologists, and clinical scientists working in the complex field of serotonin. Hence this volume provides the reader with a unique overview of the sources, effects, receptors, molecular biology, physiological actions and pathological roles of serotonin agonists and antagonists. As such the book will be of interest both to persons devoting their research efforts to serotonin as well as to all scholars and clinicians wanting to know how this powerful monoamine can modulate cellular functions.

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Book Details

Hardcover: 452 pages
Publisher: CRC Press; 1 edition (October 4, 2001)
Language: English
ISBN-10: 0748408819
ISBN-13: 978-0748408818.

Book Description

The aim of this book is, by the help of specialists in the field, to convey recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. The book is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field.

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Book Details

Paperback: 788 pages
Publisher: Saunders Ltd.; 2 edition (August 22, 2005)
Language: English
ISBN-10: 0702027545
ISBN-13: 978-0702027543.

Book Description

The smart way to study! Elsevier titles with STUDENT CONSULT will help you master difficult concepts and study more efficiently in print and online! Perform rapid searches. Integrate bonus content from other disciplines. Download text to your handheld device. And a lot more. Each STUDENT CONSULT title comes with full text online, a unique image library, case studies, USMLE style questions, and online note-taking to enhance your learning experience.

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Book Details

Paperback: 464 pages
Publisher: Bailliere Tindall; 1 edition (November 15, 1999)
Language: English
ISBN-10: 0702021679
ISBN-13: 978-0702021671.

Book Description

Second author, Michael B. Howie, is with Ohio State Univ., Columbus. Reviews principles of drug action at the cellular level, then focuses on drugs used on a daily basis. Emphasis is placed on new developments in clinical pharmacology in related areas of medicine. For anesthesiologists. Softcover.

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