Book Details

Hardcover: 493 pages
Publisher: Academic Press; 1 edition (September 21, 2000)
Language: English
ISBN-10: 0124478700
ISBN-13: 978-0124478701.

Book Description

The anticipated encore volume of the Biomedical Research Reports Series, Hepatitis C is the first book that offers comprehensive and up-to-date coverage of this “silent epidemic.” The subject matter ranges from basic science to clinical medicine, with contributions from more than 30 international experts in the field. This important new book details the hepatitis C virus and the disease that it causes, including its prevalence, means of spread, symptoms, complications, natural history, prevention, and therapy.The editors, T. Jake Liang, M.D., and Jay H. Hoofnagle, M.D., are both hepatologists and clinical and laboratory researchers who are well known leaders in the hepatitis field. Their team of authors provide the latest information on key issues such as the role of hepatitis C in liver cancer and evolving therapy for hepatitis C, including special subgroups of patients such as children, patients with renal failure, patients undergoing liver transplantation, and patients with HIV coinfection. The book also addresses future directions in antiviral therapy of hepatitis C and the real challenges of developing a vaccine. Hepatitis C is the integrated reference book for all researchers, clinicians, and students dealing with this troubling virus.

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Book Details

Hardcover: 538 pages
Publisher: Wiley; 1 edition (June 10, 2008)
Language: English
ISBN-10: 0470016744
ISBN-13: 978-0470016749.

Book Description

Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include:

• introduction to blood components and blood plasma proteins
• blood plasma protein domains, motifs and repeats
• blood plasma protein families and posttranslational modifications
• blood coagulation and fibrinolysis
• the complement system
• the immune system
• enzymes
• inhibitors
• lipoproteins
• hormones
• cytokines and growth factors
• transport and storage

The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure.

Attractively presented in full colour, Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.

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Book Details

Hardcover: 236 pages
Publisher: Imperial College Press; 1 edition (January 2, 2008)
Language: English
ISBN-10: 186094826X
ISBN-13: 978-1860948268.

Book Description

Platelets in Cardiovascular Disease provides an in-depth and current coverage of relevant platelet biology and antiplatelet therapy that is in clinical use today and potentially for the future. The book provides a succinct overview of the critical role of platelets in cardiovascular medicine.

Cardiovascular disease is the leading cause of mortality worldwide, and recent research has found that the platelet is central to the genesis of heart attacks and stroke as well as many of the complications of angioplasty and bypass surgery. An explosion of knowledge of the biology of platelets has established their important role in the formation of blood clots and, perhaps more intriguingly, their role as inflammatory cells. This growth in information has been paralleled by the development of several drugs that can interfere with platelet action and thereby improve patient outcomes. Indeed, several antiplatelet drugs already in development may ultimately lead to marked advances in both the treatment and prevention of cardiovascular disease.

Drawing upon a panel of international experts, Platelets in Cardiovascular Disease delivers a concise yet thorough review of the major developments in antiplatelet therapy. Practicing clinicians as well as those involved in the development of new antithrombotic therapies will find the book interesting and useful.

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Book Details

Hardcover: 208 pages
Publisher: Informa Healthcare; 1 edition (December 20, 2005)
Language: English
ISBN-10: 1842142623
ISBN-13: 978-1842142622.

Book Description

With notable expansion in the clinical interaction between hematologists and obstetricians over the last decade, understanding and managing the clinical manifestations of hemato-obstetric science has become increasingly important.

A new reference work in this growing field, this text is a key tool in the diagnosis and treatment of these conditions, providing the reader with a user-friendly, authoritative source of information, which incorporates best practice within internationally accepted guidelines.

Clearly presented and easy to use, each chapter includes:

* pathophysiology

* presentation

* differential diagnosis

* diagnostic tests and difficulties

* maternal, fetal, and potential management complications

* implications for screening and future management

* tables summarizing the key points in diagnosis and management.

A practical, reader-friendly book, this text will be an important resource for clinical staff involved in the management of pregnancy – from trainees in obstetrics, hematology and vascular medicine, to general practitioners involved in day-to-day maternity care, as well as midwifery staff and specialists in hematology, obstetrics and vascular medicine.

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Book Details

Hardcover: 584 pages
Publisher: Springer; 1 edition (January 12, 2004)
Language: English
ISBN-10: 3540439994
ISBN-13: 978-3540439998.

Book Description

This is one of the first books to deal specifically with imaging of the entire spectrum of hematological malignancies. The use of the latest imaging modalities is well described. In the first chapter of the book, magnetic resonance imaging of the bone marrow is discussed in detail. The following chapters describe exhaustively the imaging features of hematological malignancies, supported by thorough radiological and histological illustrations and tables. The third part documents the effects of therapy on each anatomical group of organs in patients treated in Hematology. The last part details the interventional procedures employed for diagnosis, evaluation of treatment and also therapeutic purposes. Each of the 28 chapters is written by an internationally recognized expert, making this book the most current and complete treatment of this subject available. It should be of great interest to radiologists and hematologists.

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Book Details

Hardcover: 1344 pages
Publisher: Oxford University Press, USA; 3rd edition (July 1, 2010)
Language: English
ISBN-10: 0340809477
ISBN-13: 978-0340809471.

Book Description

This comprehensive and authoritative reference covers all aspects of the group of disorders collectively known as the lymphoid neoplasms. The reader is taken through a description of its normal cellular origins and the molecular genetic abnormalities that can lead to this group of conditions, a section of the book that has been considerably strengthened for this third edition, to the environmental factors that may be relevant to disease development, and finally, to the pragmatic aspects of disease management. The authors synthesize for the reader aspects of current knowledge and likely future developments, and direct them to the appropriate resources should they wish to pursue particular avenues of scientific or literature research.

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Book Details

Hardcover: 432 pages
Publisher: Springer; 1 edition (February 29, 2000)
Language: English
ISBN-10: 0792377141
ISBN-13: 978-0792377146.

Book Description

The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogenic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft-versus-tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex-vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft-versus-host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future –a future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy.

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Book Details

Hardcover: 616 pages
Publisher: Informa Healthcare; 1 edition (March 26, 2003)
Language: English
ISBN-10: 084931528X
ISBN-13: 978-0849315282.

Book Description

Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientists present what has been accomplished thus far in developing acceptable alternatives to traditional animal toxicological assessment and provide potentially new initiatives.In over 40 chapters, the book addresses 7 themes, beginning with the validation and regulatory acceptance of alternatives in the US, the UK, and Western Europe. Then the book covers methods based on the mechanisms of eye irritation at the ocular surface, dermal toxicity testing, and assessing neurotoxicity. It also includes a case study in the use of alternatives to determine the mechanism of sulfur mustard action and discusses the role of transgenics and toxicokinetics in the development of alternative toxicity tests. Finally the book presents recent innovations in alternatives, including the use of archival data, and in silico techniques.Focusing on the science and not the politics, Alternative Toxicological Methods concisely discusses the application of state-of-the-art methods and explores cutting-edge research related to developing and validating alternatives to animal testing. This book will benefit toxicologists, cosmetic chemists, pharmacologists, experimental biologists, dermatologists, ophthalmologists, and regulatory officers in their quest for applying the 3Rs to the use of animals in toxicological testing of drug candidates, chemicals, and cosmetics.

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Book Details

Hardcover: 408 pages
Publisher: CRC Press; 1 edition (October 2, 1991)
Language: English
ISBN-10: 0849364027
ISBN-13: 978-0849364020.

Book Description

Bone Marrow Processing and Purging: A Practical Guide provides an up-to-date practical guide to the major ex vivo procedures associated with bone marrow transplantation. Previously, this information was communicated primarily by word of mouth; now experts in the field present detailed descriptions and evaluations of methods for marrow harvesting, evaluation (including tumor infiltration, flow cytometric analysis, and colony assays), comparative methods for automated nucleated cell separation and enumeration, tumor cell purging, T cell depletion, stem cell selection, gene transfer, and cytopreservation. Special sections address quality control and FDA regulations. The book provides a unique information source intended for clinicians, researchers, technical staff, transplant nurses, and medical students involved in this rapidly expanding area of medicine.

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Book Details

Hardcover: 288 pages
Publisher: Humana Press; 1 edition (September 29, 2003)
Language: English
ISBN-10: 1588290433
ISBN-13: 978-1588290434.

Book Description

Royal Hospital for Children, Bristol, UK. Offers a collection of reliable molecular techniques essential to the diagnosis, classification, and treatment of childhood hematological disorders. Discusses the latest technology for the analysis of gene expression in childhood leukemia. Protocols are explained in detail.

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